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CASE NUMBER 357
Diagnosis

Neurosarcoidosis

Note
In the left temporal lobe, there is mildly expansile T2 FLAIR hyperintensity, cortical T1 hyperintensity, and nodular leptomeningeal enhancement with few tiny foci of restricted diffusion. Findings are compatible with active inflammation with differential considerations including leptomeningeal metastasis, meningoencephalitis, primary CNS vasculitis with subacute infarction, and granulomatous infection. This is a case of neurosarcoidosis with associated vasculitis resulting in predominantly vasogenic edema with suspected cortical laminar necrosis and few foci of cytotoxic edema. Neurosarcoidosis may have a variety of CNS manifestations. Most commonly it infiltrates the dura and pia of the basilar cisterns and may involve the pituitary stalk, hypothalamus, and brainstem. Involvement of the cerebral hemispheres and the brain parenchyma as seen in this case is less common. Patients usually present with cranial nerve deficits.Treatment consists of managing symptoms with steroids with 50% showing signs of progression despite treatment.
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