Pulmonary Hemorrhage: Causes - Bleeding diathesis (leukemia, hemophilia) - Trauma - Wegeners granulomatosis - Drugs like amphotericin B and mitomycin - Infectious disease - Idiopathic pulmonary hemosiderosis
Wegener Granulomatosis: Facts
- Necrotizing vasculitis that involves small to medium vessels - May involve ear, nose, throat, lung or kidneys - Clinical presentation ranges from sinusitis to cough, fever, wheezing to hematuria
Wegener Granulomatosis: Facts
- Upper airways involved in up to 92% of cases, renal in 80% and joints in 67% - Age at dx usually 40-55 yrs - M=F but females have airway problems more commonly - Treatment with steroids and cyclophosphamide
Wegener Granulomatosis: Chest
- Cavitary nodules - Large airway stenosis - Nodules 1-10 cm in size - Consolidation with or w/o hemorrhage - Subglottic stenosis - Adenopathy uncommon