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- What does AUTOPLAQ do-
- “ AUTOPLAQ ™ software, developed at the Cedars Sinai Medical center, is a clinical research tool which allows automated 3D quantification of non-calcified and calcified plaque. The method has been described in Dey et al J Cardiovascular CT 2009;372-382”
- AUTOPLAQ ™ User Manual Version 9.5
AUTOPLAQ (Dey D et al.) 
- AUTOPLAQ Screenshot
- “The reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high when automated software is used for quantification. With this approach, serial studies to determine progression or regression of coronary atherosclerotic plaque appear to be possible.”
Interscan Reproducibility of Quantitative Coronary Plaque Volume and Composition from CT Coronary Angiography using an Automated Method
Annika Schuhbaeck, Damini Dey, Yuka Otaki, Piotr Slomka, Ryo Nakazato, Stephan Achenbach, Daniel S. Berman, Elliot Fishman, Shenghan Lai, Hong Lai
Journal of the American College of Cardiology
Volume 61, Issue 10, Supplement , Page E1040, 12 March 2013 - “The reproducibility of coronary atherosclerotic plaque volume in coronary CTA is high when automated software is used for quantification. With this approach, serial studies to determine progression or regression of coronary atherosclerotic plaque appear to be possible.”
Interscan Reproducibility of Quantitative Coronary Plaque Volume and Composition from CT Coronary Angiography using an Automated Method
Schuhbaeck A et al.
Journal of the American College of Cardiology
Volume 61, Issue 10, Supplement , Page E1040, 12 March 2013 
"The correlation of total plaque volume quantification compared by CCTA and IVUS and the interobservor and intraobservor reproducibility of these measurements is robust when the plaques are large, but they rapidly decline with decreasing plaque size."
Measuring Coronary Artery Plaque Volume and Composition by MDCT: Too Much, Too Soon?
Sola S, Desai MY
J Cardiovasc Comput Tomogr (2009) 3, 321-322"At present, highly reproducible measures of plaque detection and percentage of plaque composition are achievable, with lower levels of agreement for absolute plaque volume."
Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: An intraobservor, interobservor and interscan variability study
Cheng VY et al.
J Cardiovasc Comput Tomogr (2009) 3, 312-320"CCTA shows promise for quantifying serial coronary plaque change. Currently, the most robust measure seems to be percentage of plaque composition, rather than plaque volume. For smaller plaques, volume quantification remains challenging."
Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: An intraobservor, interobservor and interscan variability study
Cheng VY et al.
J Cardiovasc Comput Tomogr (2009) 3, 312-320"Detection and volumetry of plaques by means of MSCT shows good to moderate reproducibiity. Agreement of volume measurements depends on plaque size. Variations of relative differences decrease with increasing mean plaque volume."
Intra- and interobservor variability in detection and assessment of calcified and non calcified coronary artery plaques using 64-slice computed tomography
Hoffman H et al
Int J Cardiovasc Imaging (2008) 24:735-742"Manual stenosis measurements are significantly more accurate compared with automatic measurements, and therefore, manual adjustments are still essential for noninvasive assessment of coronary artery stenosis."
Accuracy of Noninvasive Coronary Stenosis Quantification of Different Commercially Available Dedicated Software Packages
Dikkers R et al.
J Comput Assist Tomogr 2009;33: 505-512"Whereas quantification of the amount of calcified plaque is highly standardized, no validated approach to quantify noncalcified plaque is currently available."
How do you quantify noncalcified plaque?
Schuijf JD, Bax JJ
J Cardiovascular Comput Tomogr
(2008) 2:360-365