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Potential Clinical Applications of the Cinematic Rendering Virtual Topogram

 

 

Potential Clinical Applications of the Cinematic Rendering Virtual Topogram

Linda C. Chu

The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore

 

Disclosure:

  • Elliot K. Fishman receives institutional grant support from Siemens AG and GE and is the co-founder of HipGraphics, Inc.
  • Other authors have no disclosures.

 

Overview

  • Technical aspects in generation of a virtual topogram
  • Potential applications of the virtual topogram:
    • Diagnosis of skin and soft tissue pathology
    • Detection of superficial ancillary clues to deeper pathology
    • Provide anatomic landmarks for treatment planning

 

Cinematic Rendering

  • Cinematic rendering (CR) is a recently described rendering technique inspired by quality of computer animation programs
  • It uses a global illumination model that takes direct and indirect illumination into account to generate photorealistic images
  • CR can generate these virtual topogram of the scanned volume of the skin, soft tissue, vascular, and bony structures using predefined presets
Comaniciu D et al. Med Image Anal. 2016;33:19-26. Fellner FA et al. J Biomed Sci Eng. 2016;9:170-5. Eid M et al. AJR. 2017;209(2):370-9. Johnson PT et al. AJR. 2017;209(2):309-12. Chu LC et al. Emerg Radiol. 2019;26(5):573-580.

 

Volume Rendering (VR) vs. Cinematic Rendering (CR)

Volume Rendering (VR) vs. Cinematic Rendering (CR)

Comaniciu D et al. Med Image Anal. 2016;33:19-26. Fellner FA et al. J Biomed Sci Eng. 2016;9:170-5.
Eid M et al. AJR. 2017;209(2):370-9. Johnson PT et al. AJR. 2017;209(2):309-12.

 

Traditional Topogram

  • A topogram is obtained at the beginning of every CT exam to define the CT scan range and field of view
  • Although these topograms are obtained at low dose with poor anatomic detail, they have shown to contain significant findings in up to 23% of cases
  • The abnormality present on the topogram may not be included in the CT field of view in up to 2% of cases
Traditional Topogram

Traditional Topogram

Johnson PT et al. AJR. 2014;202(6):1256-1263.

 

Virtual Topogram

  • In contrast to the traditional topogram that is obtained at the beginning of the exam, we propose that the CT volumetric data can be post-processed using cinematic rendering to generate a virtual topogram
  • These virtual topograms can be generated with skin, soft tissue, vascular, and bone presets
  • Potential to improve visualization of skin and soft tissue pathology, identify superficial ancillary clues to deeper pathology, and assist in treatment planning
Chu LC et al. Emerg Radiol. 2019;26(5):573-580.

 

Virtual Topogram

Virtual topogram with skin, soft tissue, and bone presets

Virtual Topogram

Chu LC et al. Emerg Radiol. 2019;26(5):573-580

 

Potential Applications

  • Skin and soft tissue pathology:
    • Trauma
    • Soft tissue infection and masses
    • Soft tissue defects
  • Superficial ancillary clues to deeper pathology:
    • Phakomatosis
    • Superficial collaterals with central vascular pathology
  • Treatment planning:
    • Define extent of pathology for treatment planning
    • Provide superficial anatomic landmarks

 

Skin and Soft Tissue Pathology

  • Virtual topogram in skin, soft tissue, vascular, and bone presets can readily localize the site of acute traumatic injury
  • Depict complex relationships among soft tissue, vascular, and bony injuries with photorealistic detail
  • Highlight subtle textural differences in soft tissue infections and soft tissue masses
  • Improve visualization of superficial abdominal wall defects and post-surgical findings
Chu LC et al. Emerg Radiol. 2019;26(5):573-580.

 

Trauma

36-year-old man with gunshot wound to the left thigh

Trauma

A) Coronal IV contrast-enhanced CT of the left thigh with CR soft tissue preset shows a focal soft tissue defect from gunshot wound. B) CR in vascular and soft tissue preset shows the underlying vascular injury with transection and occlusion of the left superficial femoral artery. C) CR in vascular preset fades out the soft tissues and highlights the vascular injury.

 

Trauma

52-year-old man involved in a motor vehicle accident

Trauma

A) Coronal IV contrast-enhanced CT of the chest shows extensive right chest wall deformity and subcutaneous emphysema. B-D) CR in bone presets in varying obliquities better illustrates the extent of numerous right rib fractures than the 2D image. They allow for comprehensive and efficient assessment of osseous injuries in a trauma patient.

 

Soft Tissue Infection

31-year-old woman with right arm infection and clinical concern for abscess

Soft Tissue Infection

A) Coronal IV contrast-enhanced CT of the right arm shows a loculated peripherally enhancing fluid collection in the medial right arm consistent with abscess. B) Coronal CR in soft tissue preset similarly shows the extent the abscess. C) CR in vascular preset shows patency of right arm arteries with no evidence of compromise. D) CR soft tissue topogram can be used for anatomic localization of the fluid collection for percutaneous drainage.

 

Soft Tissue Infection

36-year-old man with recent left thigh laceration repair who presents with increased thigh swelling

Soft Tissue Infection

A) Coronal IV contrast-enhanced CT of the left thigh shows a loculated peripherally enhancing fluid collection in the lateral left thigh consistent with abscess. B) Coronal CR in soft tissue preset accentuates diffuse subcutaneous edema in the left thigh and can help localize the region of interest. C) Axial CR in soft tissue preset highlights difference in texture and attenuation of the abscess relative to background soft tissues.

 

Soft Tissue Injection Granulomas

33 year-old woman with abdomen pain

Soft Tissue Injection Granulomas

A) Coronal IV contrast-enhanced CT of the pelvis shows an innumerable granulomas within bilateral gluteal soft tissues, presumably related to cosmetic procedures. B) Coronal CR in soft tissue preset accentuates the textural difference between the granulomas and subcutaneous fat.

 

Soft Tissue Metastasis

74-year-old man with metastatic melanoma to the right axilla

Soft Tissue Metastasis

A) Axial IV contrast-enhanced CT of the chest shows heterogeneous enhancing mass in the right axilla. B) Axial CR in soft tissue preset highlights the textural difference of the right axillary mass and compression of the right axillary vasculature. C) Coronal CR in soft tissue preset shows the close proximity of the right axillary mass to the underlying chest wall.

 

Soft Tissue Metastasis

57-year-old man with history of metastatic lung cancer

Soft Tissue Metastasis

A) Axial IV contrast-enhanced CT of the pelvis shows an infiltrative enhancing mass within the left gluteus musculature and subcutaneous soft tissues. B) Axial CR in soft tissue preset improves visualization of the soft tissue mass by accentuating textural difference. C) Coronal CR in vascular preset shows prominent neovascularity supplying the soft tissue metastasis.

 

Abdominal Wall Defect

50-year-old woman with Crohns disease status post bowel resection with open abdominal wall wound

Abdominal Wall Defect

A) Axial IV contrast-enhanced CT of the abdomen shows an open abdomen wall wound with small bowel herniation. B) Coronal CR in skin preset shows the extent of the abdominal wall defect and the overlying wound vacuum device. C) Coronal CR in soft tissue preset shows the underlying small bowel by altering the transparency of the CR settings.

 

Abdominal Wall Ostomy

35-year-old paraplegic man with neurogenic bowel with left lower quadrant colostomy and chronic DVTs

Abdominal Wall Ostomy

A) Coronal IV contrast-enhanced CT in maximum intensity projection (MIP) shows the left lower quadrant ostomy and prominent superficial venous collaterals from chronic DVT. B) Coronal VR illustrates the same findings with slight improvement in soft tissue differentiation. C) Coronal CR in soft tissue and vascular preset improve depth perception and visualization of these findings.

 

Superficial Clues to Deeper Pathology

  • Improve visualization of cutaneous manifestations of neurofibromatosis and other phakomatoses, which may provide clues to deeper pathology
  • Improve visualization of superficial arterial and venous collateral pathways in the setting of underlying vascular disease

 

Differential Diagnosis?

Neuroendocrine tumors
Gastrointestinal stromal tumors
Hypervascular metastases

Differential Diagnosis?

A) Coronal IV contrast-enhanced CT of the abdomen shows multiple enhancing jejunal masses.

 

Neurofibromatosis 1

57 year-old man with neurofibromatosis 1

Neurofibromatosis 1

A) Coronal IV contrast-enhanced CT of the abdomen shows multiple enhancing jejunal masses. B) Coronal CR similarly shows multiple enhancing jejunal masses. C) Coronal CR in skin preset highlights innumerable neurofibromas in the skin, consistent with neurofibromatosis 1. This clue helps to suggest the correct diagnosis of multiple gastrointestinal stromal tumors (GISTs) in the setting of neurofibromatosis 1.

 

Neurofibromatosis 1

33 year-old man with neurofibromatosis 1

Neurofibromatosis 1

A) Coronal IV contrast-enhanced CT shows numerous subcutaneous nodules consistent with neurofibromas in the setting of neurofibromatosis 1. B) Coronal VR similarly shows multiple neurofibromas. C) Coronal CR in skin preset accentuates subtle irregularities of the skin surface compared to traditional volume rendering and can improve visualization of skin pathology compared to 2D and volume rendering.

 

Aortic Occlusion

56 year-old man with chronic aortic occlusion and bilateral axillary-femoral bypass grafts

Aortic Occlusion

A) Axial IV contrast-enhanced CT partially demonstrate patent bilateral axillary-femoral grafts. B) Coronal CR in vascular soft tissue preset shows patency of bilateral axillary-femoral grafts. C) Coronal CR in vascular preset viewed in the posterior projection clearly define patency of bilateral axillary-femoral grafts and evidence of old occluded aortoiliac stents.

 

Aortic Occlusion

69 year-old woman with chronic aortic occlusive disease with occluded axillary-femoral and femoral-femoral bypass grafts

Aortic Occlusion

A) Axial IV contrast-enhanced CT shows chronic occlusion of infrarenal abdominal aorta. B) Coronal CR in vascular preset shows chronic occlusion of infrarenal aorta with reconstitution of the iliac arteries via epigastric collaterals. C) Coronal CR in vascular preset focused on superficial tissues highlight the hypertrophy of the epigastric arteries as important sources of collateralization. These collaterals are better appreciated on CR compared to 2D images.

 

SVC Occlusion

39 year-old man with chronic SVC occlusion

SVC Occlusion

A) Coronal IV contrast-enhanced CT shows chronic occlusion of SVC with prominent body wall collaterals. B) Coronal MIP better illustrates the extent of body wall collaterals compared to 2D image. C) Coronal CR in vascular and soft tissue preset shows superior soft tissue differentiation compared to MIP and portrays the findings with increased detail.

 

Portal Hypertension

54 year-old man with cirrhosis and portal hypertension

Portal Hypertension

A) Axial IV contrast-enhanced CT cirrhotic liver with recanalization of paraumbilical vein and engorgement of superficial venous collaterals, consistent with portal hypertension. B) Coronal MIP better illustrates the extent of venous collaterals compared to 2D image. C) Coronal CR in vascular and soft tissue preset improve depth perception and highlight the engorged superficial epigastric veins, with classic appearance of caput medusae.

 

Treatment Planning

  • Improve visualization of complications related to acute traumatic injuries
  • Improve visualization of complex relationships among soft tissue, muscle, vascular, and bony injuries in the setting of acute trauma to facilitate treatment planning
  • Can provide anatomic landmarks for percutaneous image guided procedures

 

Fracture Blisters

60-year-old man with right humerus fracture complicated by fracture blisters

Fracture Blisters

A) Coronal VR IV contrast-enhanced CT of the right arm shows multiple raised areas in the skin compatible with fracture blisters. B) Sagittal oblique CR in skin preset and C) Sagittal oblique CR in soft tissue preset improve the visualization of the skin blisters due to improved soft tissue differentiation and depth perception.

 

Repair of Traumatic Injuries

32-year-old man with traumatic right calf laceration

Repair of Traumatic Injuries

A) Coronal IV contrast-enhanced CT of the right calf shows a deep laceration along the medial right calf. B) Sagittal oblique VR again demonstrates the deep laceration. C) Sagittal oblique CR in soft tissue preset improves soft tissue differentiation and visualization of the underlying fascial and muscle laceration.

 

Repair of Traumatic Injuries

27-year-old man with traumatic right wrist laceration

27-year-old man with traumatic right wrist laceration

A) Coronal IV contrast-enhanced CT of the right wrist in CR skin preset shows a laceration along ulnar aspect of the wrist. B) CR in soft tissue preset shows integrity of the underlying tendons without evidence of acute injury. C) CR in vascular preset shows absence of vascular injury.

 

Venous Malformation

39-year-old woman with left gluteal venous malformation who presents for pre-operative planning

Venous Malformation

A) Coronal IV contrast-enhanced CT of the left thigh shows a few dilated veins. Full extent of the venous malformation is difficult to appreciate on 2D images. B) Coronal CR in soft tissue and vascular preset shows the extensive venous malformation and relationship with the underlying soft tissues. C) Coronal CR in soft tissue preset highlights the superficial cutaneous findings, which can be used for localization of the deeper venous malformation.

 

Limitations

  • CR uses a more complex algorithm than VR and requires higher computational power
    • Requires more powerful workstations and network bandwidth
    • Each manipulation during interactive rendering requires a new set of calculations → Long post-processing time compared to VR
  • CR presets may require optimization on an individual basis to optimally display the pathology
  • Further research is needed to determine whether the photorealism improves diagnostic accuracy and/or outcomes

 

Conclusion

  • Volumetric CT dataset can be post-processed with cinematic rendering to generate virtual topograms in skin, soft tissue, vascular, and bone presets
  • Virtual topograms have the potential to improve visualization of acute traumatic injuries, inflammatory conditions, and neoplastic diseases affecting the skin the soft tissues
  • Improved visualization of the skin and subcutaneous findings may provide clues for underlying deeper pathology and assist in pretreatment planning

 

References

  • Calhoun PS et al. Radiographics. 1999;19(3):745-64.
  • Chu LC et al. Emerg Radiol. 2019;26(5):573-580.
  • Comaniciu D et al. Med Image Anal. 2016;33:19-26.
  • Eid M et al. AJR. 2017;209(2):370-9.
  • Fellner FA et al. J Biomed Sci Eng. 2016;9:170-5.
  • Johnson PT et al. AJR. 2014;202(6):1256-1263.
  • Johnson PT et al. AJR. 2017;209(2):309-12.

Acknowledgements

  • Linda C. Chu
  • Steven P. Rowe
  • Saeed Ghandili
  • Daniel F. Fouladi
  • Alejandra Blanco
  • Shahab Shayesteh
  • Elliot K. Fishman

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