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CT of Sclerosing Mesenteritis: A Challenging Diagnosis

CT of Sclerosing Mesenteritis: A Challenging Diagnosis

Elliot K. Fishman M.D.
Professor of Radiology, Surgery, Oncology and Urology
Johns Hopkins Hospital

Click here to view this module as a video lecture.

 

Sclerosing Mesenteritis: Facts

  • Idiopathic disorder with chronic, nospecific inflammation, fat necrosis and fibrosis
  • Usually involves the small bowel mesentery but may involve the colonic mesocolon
  • Synonyms include;
    • Mesenteric panniculitis
    • Retractile mesenteritis
    • Mesenteric lipodystrophy
    • Lipogranuloma of the mesentery

 

"Sclerosing mesenteritis is a rare inflammatory condition of unknown cause that affects the root of the mesentery. The mesenteric fat is involved with a variable amount of inflammation, fatty necrosis, and fibrosis. When the inflammation predominates (so-called mesenteric panniculitis), patients generally present with acute pain. On CT images, mesenteric panniculitis appears as a focal area of increased attenuation within the mesenteric fat surrounded by a pseudocapsule, an appearance that has been described as "the misty mesentery". Areas of fibrosis within the inflamed fat appear as linear bands of soft-tissue attenuation ."
Mesenteric Neoplasms: CT Appearances of Primary and Secondary Tumors and Differential Diagnosis
Sheth S, Horton KM, Garland MR, Fishman EK
RadioGraphics Mar 2003, Vol. 23, No. 2:457–473

 

Sclerosing Mesenteritis: Facts

  • Average age of presentation is 60 years
  • More common in men by 2-1
  • Abdominal pain is the most common presentation but weight loss, distension, and FUO are other presentations

 

Sclerosing Mesenteritis: CT Findings

  • Retraction and shortening of small bowel mesentery
  • Partial or complete SBO
  • Well defined or ill-defined mesenteric mass with soft tissue or mixed fat and soft tissue attenuation
  • May encase mesenteric vessels with preservation of fatty collar around the vessels (“fat ring sign”)
  • Punctate or coarse calcifications may be seen

 

Sclerosing Mesenteritis: Differential Diagnosis

  • Carcinoid tumor
  • Metastatic disease to mesentery
  • Lymphoma
  • Soft tissue sarcomas
  • Weber Christian disease

 

“At CT, the most common manifestation of mesenteric carcinoid tumors is that of an enhancing soft-tissue mass with linear bands radiating in the mesenteric fat . Radiologic-pathologic correlation has shown that these radiating strands of soft tissue do not generally represent tumor infiltration along neurovascular bundles but rather result from the intense fibrotic proliferation and desmoplastic reaction in the mesenteric fat and the adjacent mesenteric vessels caused by the release of serotonin and other hormones from the primary tumor ."
Mesenteric Neoplasms: CT Appearances of Primary and Secondary Tumors and Differential Diagnosis
Sheth S, Horton KM, Garland MR, Fishman EK
RadioGraphics Mar 2003, Vol. 23, No. 2:457–473

 

Abdominal Pain

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

Sclerosing Mesenteritis

CT of Sclerosing Mesenteritis

 

Abdominal Pain

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

Sclerosing Mesenteritis

Sclerosing Mesenteritis

 

Abdominal Pain

CT of Sclerosing Mesenteritis

 

Sclerosing Mesenteritis

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

SBO due to Sclerosing Mesenteritis

SBO due to Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

CT of Sclerosing Mesenteritis

 

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