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CT Evaluation of Small Bowel Tumors: Detection & Classification

CT Evaluation of Small Bowel Tumors: Detection & Classification

Elliot K. Fishman M.D.
Johns Hopkins Hospital

Click here to view this module as a video lecture.

 

“Although the small intestine accounts for over 90% of the surface area of the alimentary tract, tumors of the small intestine represent less than 5% of all gastrointestinal tract neoplasms. Common small bowel tumors typically are well evaluated with cross-sectional imaging modalities such as CT and MR, but accurate identification and differentiation can be challenging. Differentiating normal bowel from abnormal tumor depends on imaging modality and the particular technique.”
Multimodality imaging of small bowel neoplasms.
Williams EA1, Bowman AW2
Abdom Radiol 2019 Jun;44(6):2089-2103

 

“Differentiating normal bowel from abnormal tumor depends on imaging modality and the particular technique. While endoscopic evaluation is typically more sensitive for the detection of intraluminal tumors that can be reached, CT and MR, as well as select nuclear medicine studies, remain superior for evaluating extraluminal neoplasms. Understanding the imaging characteristics of typical benign and malignant small bowel tumors is critical, because of overlapping features and associated secondary complications.”
Multimodality imaging of small bowel neoplasms.
Williams EA1, Bowman AW2
Abdom Radiol 2019 Jun;44(6):2089-2103

 

CTA of the Small Bowel: Scan Protocol

Oral contrast
  • Water
  • Omnipaque-350
  • VoLumen
Intravenous contrast
  • 100-120 cc of Omnipaque-350 (Visipaue 320)
  • Injection rate of 4-5 cc/sec

 

CTA in the Abdomen: Applications

Patient preparation
  • Oral contrast
    • 1000 cc of water given over a 20-30 minute period
  • IV contrast
    • 80-120 cc of non-ionic contrast ( usually at 320-350 concentration like iohexol-350 or iodixanol-320) injected at 4-5 cc/sec

 

CTA in the Abdomen: Applications

Scan Protocol Selection
  • Arterial phase imaging
  • Venous phase imaging
  • Role of non-contrast CT
  • Role of delayed phase imaging

 

3D CT Angiography Protocol: Small Bowel Arterial Phase (64MDCT and Beyond)

CT of Small Bowel Tumors

 

CTA in the Abdomen: Applications

Data Analysis Tools
  • Axial
  • MPR (coronal/sagittal)
  • Curved planar reconstruction (CPR)
  • Volume rendering technique (VRT)
  • Maximum intensity projection (MIP)

 

Do you see the duodenal mass?

Do you see the duodenal mass?

 

Subtle Tumor Duodenal Carcinoid

Subtle Tumor Duodenal Carcinoid

 

Coronal and VRT Views

Coronal and VRT Views

 

CT of Small Bowel Tumors

 

Small Bowel GIST Missed with Positive Contrast

Small Bowel GIST Missed with Positive Contrast

 

CT of Small Bowel Tumors

 

6 months later

6 months later

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

“Small bowel cancer is a rare malignancy that comprises less than 5 % of all gastrointestinal malignancies. The estimated annual incidence is 0.3–2.0 cases per 100,000 persons, with a higher prevalence rates in the black population than the white, and has been recently increasing. It is most frequently diagnosed among people aged 55–64, with the incidence increasing after age 40. The current 5-year survival rate in the USA is 65.5 %; cancer stage at diagnosis has a strong influence on the length of survival.”
Small bowel adenocarcinoma of the jejunum: a case report and literature review
Li J et al.
World Journal of Surgical Oncology 2016; 14:177

 

Common Cancer Numbers

Common Cancer Numbers

 

Small Bowel Cancer: By The Numbers

Small Bowel Cancer: By The Numbers

 

“Cancer of the small intestine is very uncommon. There are 4 main histological subtypes: adenocarcinomas, carcinoid tumors, lymphoma and sarcoma. The incidence of small intestine cancer has increased over the past several decades with a four-fold increase for carcinoid tumors, less dramatic rises for adenocarcinoma and lymphoma and stable sarcoma rates.”
Epidemiology of cancer of the small intestine
Pan SI, Morrison H
World J Gastrointest Oncol 2011 March 15; 3(3):33-42

 

Small Bowel Tumors: Frequency

  • Adenocarcinoma 30-40%
  • Carcinoid tumors 35-42%
  • Lymphoma 15-20%
  • Sarcomas 15-20%

 

Adenocarcinoma of the Small Bowel-CT Appearance

  • diffuse infiltration of a segment of bowel
  • polypoid mass
  • constricting lesion
  • large ulcerating lesion

 

Adenocarcinoma of the Small Bowel- Facts

  • more common in the proximal bowel (duodenum> jejunum> ileum)
  • variable clinical presentation
  • increased frequency in certain associated conditions (i.e. crohn disease, sprue)

 

Small Bowel Neoplasms

Risks
  • Diet.
    • Eating high-fat foods may raise the risk of small bowel cancer. Regularly consuming smoked or cured foods may also increase a person’s risk.
  • Crohn disease.
  • Celiac disease.
  • Familial adenomatous polyposis (FAP).

 

Small Bowel Neoplasms

Presentation
  • Pain, nausea, vomiting
  • Weight loss, obstruction
  • GI bleeding
  • Lack of reliable clinical findings
Usually significant delay in diagnosis

 

Duodenal Carcinoma Arising in a Villous Adenoma

Duodenal Carcinoma Arising in a Villous Adenoma

 

CT of Small Bowel Tumors

 

Duodenal Adenocarcinoma

Duodenal Adenocarcinoma

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

Hx-abdominal pain and weight loss

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

Small Bowel Adenocarcinoma

Small Bowel Adenocarcinoma

 

Adenocarcinoma Duodenum

Adenocarcinoma Duodenum

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

CT of Small Bowel Tumors

 

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