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“An indeterminate adrenal lesion that enhances greater than 130 HU on multidetector CT cannot be assumed to be an adenoma. Hypervascular pheochromocytoma (>130 HU) mimics adenoma washout pattern; absolute venous phase enhancement level must be considered.”
Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics.
Northcutt BG, Trakhtenbroit MA, Gomez EN, Fishman EK, Johnson PT.
J Comput Assist Tomogr. 2016 Mar-Apr;40(2):194-200.

 

Objective: To evaluate the proportion of pheochromocytomas meeting the criteria for adenoma on adrenal washout CT and the diagnostic performance of adrenal washout CT for differentiating adenoma from pheochromocytoma.
Conclusions: There was a non-negligible proportion of pheochromocytomas meeting the criteria for adenoma on adrenal washout CT. Although overall diagnostic performance was excellent for differentiating adenoma from pheochromocytoma, specificity was relatively low.
Pheochromocytoma as a frequent false-positive in adrenal washout CT: A systematic review and meta-analysis.
Woo S, Suh CH, Kim SY, Cho JY, Kim SH.
Eur Radiol. 2018 Mar;28(3):1027-1036.

 

Key points: 
• Non-negligible proportion of pheochromocytomas can be mistaken for adenoma.
• Adrenal washout CT showed good sensitivity (97%) but relatively low specificity (67%).
• Findings other than washout percentage should be used when diagnosing pheochromocytomas.
Pheochromocytoma as a frequent false-positive in adrenal washout CT: A systematic review and meta-analysis.
Woo S, Suh CH, Kim SY, Cho JY, Kim SH.
Eur Radiol. 2018 Mar;28(3):1027-1036.

 

“ Pheochromocytomas are often considered the great mimicker of other adrenal tumors. Because of their varied clinical, imaging, and pathologic appearances, accurate diagnosis can be challenging.”
Pheochromocytoma: The Range of Appearances on Ultrasound, CT, MRI, and Functional Imaging
Leung K et al.
AJR 2013; 200:370-378

 

Pheochromocytoma: CT Findings

  • Calcifications are found in 10% of Pheochromocytomas
  • Pheochromocytomas typically are vascular on early phase CT scans
  • Pheochromocytomas can have a 50% washout value and behave just like an adenoma
  • In the absence of metastases it is hard to diagnosis whether or not a Pheochromocytoma is malignant

 

1 cm Pheochromocytoma

1 cm Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Pheo Left Adrenal

Pheo Left Adrenal

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Incidental Finding

Incidental Finding

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Cystic Adrenal Mass: Pheochromocytoma

Cystic Adrenal Mass: Pheochromocytoma

 

“Cystic appearance was present in 12/22 (55%, 95% CI 32-76%) pheochromocytomas (mean size 5.3 cm), 15/34 (44%, 95% CI 27-62%) malignant masses (mean size 5.8 cm), and 2/36 (5.6%, 95% CI 0.7-9%) adenomas (mean size 3.2 cm). Sensitivity and specificity of cystic appearance for distinguishing pheochromocytoma or malignant masses from adenomas were 48.2% (95% CI 34.7-62.0%) and 94.4% (95% CI 81.3-99.3%), respectively. Cystic appearance was a significant predictor of tumor type (p = 0.015) even after controlling for tumor size. Reader agreement for cystic appearance was almost perfect with a kappa of 0.85.”
Accuracy of focal cystic appearance within adrenal nodules on contrast-enhanced CT to distinguish pheochromocytoma and malignant adrenal tumors from adenomas.
Corwin MT et al.
Abdom Radiol (NY). 2021 Jan 8. doi: 10.1007/s00261-020-02925-5. 

 

Phechromocytoma (7.2cm)

Phechromocytoma (7.2cm)

 

LUQ Pain

LUQ Pain

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Incidental Pheochromocytoma

Incidental Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Pheochromocytoma

Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Pheochromocytoma

Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

Adrenal Pheochromocytoma

 

 
 

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