Well-differentiated Liposarcoma, Left Thigh

42-year-old male with gradually enlarging left thigh mass. Images demonstrate a multiseptated T1 hyperintense, STIR hypointense, heterogeneously enhancing mass enveloping the left femoral diaphysis and extending into the surrounding soft tissues. No periosteal reaction. There are enhancing, wispy, septations on the postcontrast images with more nodular excrescences at the inferior most aspect of the mass. On resection, this lesion was found to be a well-differentiated liposarcoma, which represents the second most common soft tissue sarcoma. Liposarcoma typically arise in adults between the ages of the 40 and 60 years. Typical locations include the extremities or retroperitoneum. Well-differentiated liposarcoma is the most common subtype, occurring in greater than 50% of cases. Extremity liposarcomas are typically slow growing and have variable rates of localized disease recurrence with deeper lesions more likely to recur. Primary surgical treatment is with wide local excision.