Results of 10-year mobile low-dose computed tomography screenings for lung cancer in Shimane, Japan
Megumi Hamaguchi, Yukari Tsubata, Akari Tanino, Yuki Mitarai, Kojiro Hata, Misato Kobayashi, Yohei Shiratsuki, Takae Okuno, Mika Nakao, Yoshihiro Amano, Kazuhisa Nakashima, Takamasa Hotta, Shunichi Hamaguchi, Taishi Nagao, Noriaki Kurimoto, Takeshi Isobe
Respir Investig . 2022 Mar;60(2):215-220. doi: 10.1016/j.resinv.2021.10.001. Epub 2021 Nov 2.
Background: Some randomized controlled trials have evaluated the effects of low-dose computed tomography (CT) screening on lung cancer mortality in heavy smokers. Based on the results of those trials, our CT screening program recommended screening for people aged ≥40 years with a history of smoking. This retrospective study aimed to verify the validity of our CT screening program and elucidate the current state of CT screening program.
Methods: We retrospectively examined lung cancer detection in 25,189 participants who underwent chest CT screening by a mobile low-dose CT screening unit in the 10-year period from April 2009 to March 2019. Participants were recruited at Japan Agricultural Cooperatives (JA) Shimane Kouseiren. Participants requested CT screening for lung cancer. CT images were read by two pulmonologists.
Results: Lung cancer was identified in 82 of the 25,189 participants over 10 years, an overall lung cancer detection rate (percentage of lung cancers detected among all participants) of 0.33%. Lung cancer among never smokers accounted for 54.9% of the detected cases. The lung cancer detection rate was similar for smokers versus never smokers. The stage IA detection rate (percentage of stage IA lung cancers among all lung cancers detected) was 62%, while the stage Ⅳ detection rate was 10%.
Conclusions: Chest CT detected lung cancer in never smokers as well as current or former smokers. Our CT screening program was not effective for never smokers; thus, further study of the effectiveness of CT screening in never smokers is needed.
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