Weakly unsupervised conditional generative adversarial network for image-based prognostic prediction for COVID-19 patients based on chest CT
Tomoki Uemura, Janne J Näppi, Chinatsu Watari, Toru Hironaka, Tohru Kamiya, Hiroyuki Yoshida
Med Image Anal . 2021 Oct;73:102159. doi: 10.1016/j.media.2021.102159. Epub 2021 Jul 11.
Because of the rapid spread and wide range of the clinical manifestations of the coronavirus disease 2019 (COVID-19), fast and accurate estimation of the disease progression and mortality is vital for the management of the patients. Currently available image-based prognostic predictors for patients with COVID-19 are largely limited to semi-automated schemes with manually designed features and supervised learning, and the survival analysis is largely limited to logistic regression. We developed a weakly unsupervised conditional generative adversarial network, called pix2surv, which can be trained to estimate the time-to-event information for survival analysis directly from the chest computed tomography (CT) images of a patient. We show that the performance of pix2surv based on CT images significantly outperforms those of existing laboratory tests and image-based visual and quantitative predictors in estimating the disease progression and mortality of COVID-19 patients. Thus, pix2surv is a promising approach for performing image-based prognostic predictions.
Read Full Article Here: https://doi.org/10.1016/j.media.2021.102159