Current update on the molecular genetics and management of hereditary ovarian cancers: a primer for radiologists
Abdom Radiol (NY) . 2021 Jun;46(6):2281-2292. doi: 10.1007/s00261-020-02911-x. Epub 2021 Apr 13.
Malak Itani, Neeraj Lalwani, Dhakshinamoorthy Ganeshan, Maria Zulfiqar, Cary Siegel
More than one-fifth of ovarian cancers are hereditary, with most of them caused by BRCA genes. Malignant ovarian neoplasms are primarily epithelial tumors, a heterogeneous group of tumors with variable genetic backgrounds that translate into different biologic behaviors and morphologic features. Radiologists play an increasingly important role in the diagnosis and management of oncology patients. Familiarity with hereditary ovarian cancers will have a positive impact on patient management and radiologists' involvement in the multidisciplinary approach needed for this delicate patient population. In this paper, we review the basic histologic and genetic backgrounds of ovarian tumors with an emphasis on hereditary ovarian cancers, as well as the effects that these factors have on patient workup, primarily with regard to imaging studies.
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