Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets
Nat Commun . 2020 Aug 14;11(1):4080. doi: 10.1038/s41467-020-17971-2.
Stephanie A Harmon, Thomas H Sanford, Sheng Xu, Evrim B Turkbey, Holger Roth, Ziyue Xu, Dong Yang, Andriy Myronenko, Victoria Anderson, Amel Amalou, Maxime Blain, Michael Kassin, Dilara Long, Nicole Varble, Stephanie M Walker, Ulas Bagci, Anna Maria Ierardi, Elvira Stellato, Guido Giovanni Plensich, Giuseppe Franceschelli, Cristiano Girlando, Giovanni Irmici, Dominic Labella, Dima Hammoud, Ashkan Malayeri, Elizabeth Jones, Ronald M Summers, Peter L Choyke, Daguang Xu, Mona Flores, Kaku Tamura, Hirofumi Obinata, Hitoshi Mori, Francesca Patella, Maurizio Cariati, Gianpaolo Carrafiello, Peng An, Bradford J Wood, Baris Turkbey
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differentiation of COVID-19 findings from other clinical entities. Here we show that a series of deep learning algorithms, trained in a diverse multinational cohort of 1280 patients to localize parietal pleura/lung parenchyma followed by classification of COVID-19 pneumonia, can achieve up to 90.8% accuracy, with 84% sensitivity and 93% specificity, as evaluated in an independent test set (not included in training and validation) of 1337 patients. Normal controls included chest CTs from oncology, emergency, and pneumonia-related indications. The false positive rate in 140 patients with laboratory confirmed other (non COVID-19) pneumonias was 10%. AI-based algorithms can readily identify CT scans with COVID-19 associated pneumonia, as well as distinguish non-COVID related pneumonias with high specificity in diverse patient populations.
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