Characteristic Radiological Features of Retrospectively Diagnosed Pancreatic Cancers
Pancreas . 2020 Jan;49(1):76-88. doi: 10.1097/MPA.0000000000001456.
Daizo Fukushima, Noriyuki Nishino, Koichi Hamada, Yoshinori Horikawa, Yoshiki Shiwa, Shinya Nishida, Ryota Koyanagi, Tsuyoshi Abe, Nobuyasu Suzuki, Yoshinao Takano, Yasushi Teranishi, Hirotsugu Munechika, Yoshihiro Miura, Tatsuhiko Nakasato, Hideo Sakuma
Objectives: The aim of this study was to assess the characteristic radiological features of early-stage pancreatic cancer (PC).
Methods: Between 2009 and 2016, 510 PC patients were selected from our hospital cancer registry database based on International Classification of Diseases for Oncology-3 (C25). Among them, 64 patients (42 males and 22 females; median age, 74 [range, 59-91]) had received repeated abdominal radiological examinations before their diagnosis of PC and were retrospectively investigated for specific radiological findings. The subjects underwent the following imaging examinations: computed tomography, magnetic resonance imaging, and fluoroglucose-positron emission tomography.
Results: Characteristic radiological features before diagnosis of PC were classified into the following 9 features: pancreatic duct ectasia (n = 16), focal low-density area (n = 15), change of cyst size (n = 8), localized tissue atrophy (n = 7), distal atrophy (n = 4), mass in pancreatic lipomatosis tissue (n = 2), mass concomitant with the already known cyst (n = 2), protrusion (n = 1), and parenchymal disproportion (n = 1). Fifty-three cases (84%) had more than one characteristic radiological feature before diagnosis of PC, and their median observation period until diagnosis was 24 (range, 1-120) months.
Conclusions: The 9 characteristic radiological features provide an opportunity to diagnose PC at an early stage.
Read Full Article Here: https://doi.org/10.1097/mpa.0000000000001456