CT-based machine learning model to predict the Fuhrman nuclear grade of clear cell renal cell carcinoma.
Abdom Radiol (NY). 2019 Jul;44(7):2528-2534. doi: 10.1007/s00261-019-01992-7.
Lin F1,2, Cui EM3, Lei Y2, Luo LP4.
PURPOSE: To predict the Fuhrman grade of clear cell renal cell carcinoma (ccRCC) with a machine learning classifier based on single- or three-phase computed tomography (CT) images.
MATERIALS AND METHODS: Patients with pathologically proven ccRCC from February 1, 2009 to September 31, 2018 who were not treated were retrospectively collected for machine learning-based analysis. The texture features were extracted and ranked from precontrast phase (PCP), corticomedullary phase (CMP), nephrographic phase (NP) and three-phase CT images, and open-source gradient boosting from the decision tree library of CatBoost was used to establish a machine learning classifier to differentiate low- from high-grade ccRCC. The performances of machine learning classifiers based on features from single- and three-phase CT images were compared with each other.
RESULTS: A total of 231 patients with 232 pathologically proven ccRCC lesions were retrospectively collected. 35, 36, 41, and 22 Features were extracted and ranked from PCP, CMP, NP, and three-phase CT images, respectively. The machine learning model based on three-phase CT images [area under the ROC curve (AUC) = 0.87] achieved the best diagnostic performance for differentiating low- from high-grade ccRCC, followed by single-phase NP (AUC = 0.84), CMP (AUC = 0.80), and PCP images (AUC = 0.82).
CONCLUSION: Machine learning classifiers can be promising noninvasive techniques to differentiate low- and high-Fuhrman nuclear grade ccRCC, and classifiers based on three-phase CT images are superior to those based on features from each single phase.
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