Why is Pancreatic Cancer so Deadly? The Pathologist's View.
J Pathol. 2019 Mar 5. doi: 10.1002/path.5260. [Epub ahead of print]
Hruban RH1, Gaida MM2, Thompson E1, Hong SM1,3, Nöe M1, Brosens LAA4,5, Jongepier M4, Offerhaus GJA4, Wood LD1.
The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated, contributor to the aggressiveness of this disease.