Consistency of quantitative analysis of coronary computed tomography angiography.
J Cardiovasc Comput Tomogr. 2019 Jan - Feb;13(1):48-54. doi: 10.1016/j.jcct.2018.09.012. Epub 2018 Oct 1.
Lee SE1, Park HB2, Xuan D3, Lee BK4, Hong MK5, Jang Y5, Chang HJ6.
BACKGROUND: The present study aimed to assess the reliability and reproducibility of coronary computed tomography angiography (CCTA) for the serial quantitative assessment of plaque volume.
METHODS: Patients who underwent repeated CCTA scans within 90 days were retrospectively screened and enrolled. Clinical data and CCTA imaging data were collected. Paired CCTA scans were analyzed using the quantitative method by separate observers blinded to the other paired CCTA scans. Results were compared between the index CCTA and follow-up CCTA.
RESULTS: Paired CT scans of 95 patients (61â€¯±â€¯13 years; 56.8% men) with same tube voltages (kVp) at both CCTAs and 24 patients (57â€¯±â€¯19 years; 48.3% men) with different kVp at two CCTAs were analyzed. In patients with same kVp at both CCTAs, there were no difference in PV and PVs of each components in per-segment analysis and per-lesion analysis (all pâ€¯>â€¯0.05). In per-lesion analysis of CCTAs from patients who used different kVp between two CCTAs, lesion length, area and diameter stenosis, and PVs were not different between index and follow-up CCTAs (all pâ€¯>â€¯0.05). Segment length and PV were also showed no difference between two serial CCTAs in per-segment analysis.
CONCLUSION: We showed the reproducibility and reliability of quantitative analysis of CCTA for assessment of coronary plaques. CCTA can be applied for the serial quantitative assessment of coronary artery disease progression, regardless of differences in the image acquisition protocol.