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Everything you need to know about Computed Tomography (CT) & CT Scanning

MDCT of the Spleen:  Splenic Metastases


Metastatic disease rarely affects the spleen in comparison to other organs, despite the spleen's large quantity of lymphoid tissue and filtration of systemic blood flow. Multiple theories have been proposed to explain the spleen's scarcity of metastatic involvement, though none fully satisfying. While metastases are rare, it is more common than primary splenic neoplasms. The incidence of splenic metastasis at autopsy has been reported at 2-8%.

Primary tumors commonly associated with splenic metastasis include lung, breast, melanoma, ovary, and colon, with malignant melanoma being the most common.

On contrast enhanced CT, splenic metastases vary in size from a few millimeters to several centimeters, but predominately appear as small, hypodense lesions often with faint peripheral contrast enhancement. This appearance can easily mimic infections processes and differentiation is made through a combination of clinical presentation and histopathologic correlation. Tumors that can develop cystic metastasis, including ovary, breast, and melanoma, can be difficult to distinguish from splenic cysts. Therefore, subtle enhancement should be carefully evaluated on contrast enhanced CT. Peritoneal implants from ovarian, pancreatic and gastrointestinal tumors may implant on the splenic capsule causing a scalloped appearance. Calcification may be present in metastasis from mucinous tumors such as adneocarcinoma of the gastrointestinal tract or cystadenocarinoma of the ovary.




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