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Everything you need to know about Computed Tomography (CT) & CT Scanning

MDCT of the Spleen: Pathology: Hamartoma


Hamartomas of the spleen are rare, benign tumors. These entities are composed of an aberrant mixture of normal splenic elements forming a mass. There are three histologic subtypes of these tumors. The first develops from white pulp consisting of aberrant lymphoid tissue. The second is the red pulp subtype comprised of aberrant complex of sinusoids. However, most commonly, harmartomas consist of a mixture of red and white pulp elements. These tumors are also known as splenoadenomas, fibrospenomas, and nodular hyperplasia of the spleen.

Hamartomas are asymptomatic unless producing left upper quadrant pain from splenomegaly. Typically these are discovered incidentally or found at autopsy. On noncontrast CT the tumor is isodense to the spleen. The only clue to their existence on noncontrast exams is if calcifications are present. Calcifications are typically punctate or stellate. Following IV contrast administration, hamartomas become more apparent as they are slightly hypodense relative to normal spleen and demonstrate prolonged enhancement on delayed images. Hamartomas of the spleen may be associated with others in different locations of the body such as in patients with tuberous sclerosis.



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