AJR:193, November 2009
Caroline Keyzer, Pierre Cullus, Denis Tack, Viviane De Maertelaer, Pascale Bohy, Pierre Alain Gevenois
OBJECTIVE. The objective of this study was to prospectively investigate the influence of oral, IV, and oral and IV contrast media on the information provided by MDCT at standard and simulated low radiation doses,in adults suspected of having acute appendicitis.
MATERIALS AND METHODS. One hundred thirty-one consecutive patients (80 wom_en, 51 men; age range, 18-87 years; mean age, 37 years) suspected of having appendicitis were randomly assigned to either ingest or not ingest iodinated contrast material. Thereafter, all patients underwent IV unenhanced and enhanced abdominopelvic MDCT with a 4 x 2.5 mm collimation at 120 kVp and 100 mAseff. Dose reduction corresponding to 30 mAseff was simulated. Two radiologists independently read scans during separate sessions, assessed ap_pendix visualization, and proposed a diagnosis (i.e., appendicitis or an alternative diagnosis). The final diagnosis was based on either surgical findings or clinical follow-up. Data were an_alyzed by factorial analysis of multiple correspondences followed by an ascending hierarchic classification method.
RESULTS. Factorial analysis and ascending hierarchic classification revealed that, in terms of diagnostic correctness, reader influence predominated over the influence of IV and oral contrast media use and radiation dose but that correctness was also influenced by the pa_tient's sex (p = 0.048) and was lower in cases of alternative diseases (p < 0.001). Visualiza_tion of the appendix depended predominantly on the reader rather than on the use of IV, oral, or oral and IV contrast agents or on radiation dose.
CONCLUSION. Diagnostic correctness is much more influenced by the reader than by the use of contrast medium (oral, IV, or both) or of simulated low-radiation-dose technique.