Whole-Body MR Imaging in Cancer Detection: Protocols, Practices, and Future Directions

Anwar R Padhani, Dow-Mu Koh, Giuseppe Petralia
Radiol Clin North Am. 2026 May;64(3):429-441. doi: 10.1016/j.rcl.2026.01.002. Epub 2026 Feb 20.
Abstract
Whole-body (WB) MR imaging is practical for staging and monitoring cancers such as multiple myeloma, prostate and breast cancers. Increasingly, WB MR imaging is increasingly used to provide reassurance and detect cancers opportunistically. This article details the Oncologically relevant findings Reporting and Data System for consistent image acquisition, interpretation, and reporting. Studies show cancer detection rates of about 1% to 2% in asymptomatic populations. Challenges include high rates of incidental findings; however, multiparametric characterization limits overdiagnosis. Clear communication with participants and physicians, the careful use of interventions, and expert interpretation are vital to minimizing harm.