The future of pancreatic cancer therapy: getting better, but not good enough yet

Johannes Klose, Jessica Doebereiner, Yoshiaki Sunami, Artur Rebelo, Ulrich Ronellenfitsch, Jorg Kleeff
Arch Med Res. 2025 Oct 30;56(8):103336. doi: 10.1016/j.arcmed.2025.103336. Online ahead of print.
Abstract
Diagnosis of pancreatic cancer is generally regarded as dismal with poor prognosis due to advanced stage at presentation and limited treatment options. In the last years, treatment options for patients with pancreatic cancer, even in advanced stages of disease, improved. Beside tailored-approaches including chemotherapies in neo or adjuvant intention, new targets as well as vaccination has been implemented into therapeutic strategies. Additionally, embedded into individual treatment strategies, surgical approached were refined providing the potential chance for cure even in metastatic disease. The aim of this review article is to describe current and further treatment options for patients with pancreatic cancer showing promising results. However, more efforts are needed to further improve patients' prognosis.