Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models-A Randomized Clinical Trial

Ozan Unlu, Matthew Varugheese, Jiyeon Shin, Samantha M Subramaniam, David Walter Jacques Stein, John J St Laurent, Charlotte J Mailly, Marian J McPartlin, Fei Wang, Michael F Oates, Christopher P Cannon, Benjamin M Scirica, Kavishwar B Wagholikar, Samuel J Aronson, Alexander J Blood

JAMA . 2025 Feb 17:e2428047. doi: 10.1001/jama.2024.28047. Online ahead of print.

Summary

This randomized clinical trial compares the efficiency of prescreening patients with heart failure using an artificial intelligence (AI) large language model for inclusion in a clinical trial vs manual prescreening.