Jiawei Liu, Jian Ling, Lujie Li, Yuxin Wu, Chenyu Song, Siya Shi, Zhi Dong, Jifei Wang, Mimi Tang, Shi-Ting Feng, Yanji Luo, Danyang Xu
Abdom Radiol (NY) . 2024 Dec 19. doi: 10.1007/s00261-024-04764-0. Online ahead of print.
Pancreatic neuroendocrine neoplasms (pNENs) are the second most common pancreatic malignancy. While most cases are sporadic, a small proportion is associated with genetic syndromes, such as Multiple Endocrine Neoplasia (MEN), Von Hippel-Lindau Syndrome (VHL), Neurofibromatosis Type 1 (NF1), and Tuberous Sclerosis Complex (TSC). This review aims to use pNENs as a clue to reveal the full spectrum of disease, providing a comprehensive understanding of diagnosis. It aids in promptly identifying abnormalities in other organs, recognizing familial genetic mutations, and achieving personalized treatment.