Hiroyuki Kato, Nabeel Bardeesy
Cell Res . 2024 May 27. doi: 10.1038/s41422-024-00982-9. Online ahead of print.
Braxton and colleagues used 3D histological reconstruction and multi-region genomic analysis to understand the microanatomy and model the progression of pancreatic intraepithelial neoplasias (PanINs), precursors of pancreatic ductal adenocarcinoma (PDAC). Their study revealed the unexpected prevalence, spatial distribution, and genetic heterogeneity of PanINs, illuminating their developmental trajectories toward PDAC.