OBJECTIVE. The purpose of this review is to describe the role of imaging and associ- ated findings in the diagnosis of blue rubber bleb nevus syndrome, Proteus syndrome, Klip- pel-Trenaunay syndrome, and Kasabach-Merritt syndrome.
CONCLUSION. Blue rubber bleb nevus, Proteus, Klippel-Trenaunay, and Kasabach- Merritt syndromes are a diverse group of vascular malformation and hemangiomatosis syn- dromes. Both cutaneous and visceral vascular lesions are associated with these disorders. Accurate diagnosis of these syndromes is important because they can be associated with serious complications, including life-threatening hemorrhage.