Purpose: To examine trabecular microarchitecture with high-reso�lution flat-panel volume computed tomography (CT) and bone mineral density (BMD) with dual-energy x-ray ab�sorptiometry (DXA) in adolescent girls with anorexia ner�vosa (AN) and to compare these results with those in normal-weight control subjects.
Materials and Methods: The study was approved by the institutional review board and complied with HIPAA guidelines. Informed consent was obtained. Twenty adolescent girls, 10 with mild AN (mean age, 15.9 years; range, 13-18 years) and 10 age-and sex-matched normal-weight control subjects (mean age, 15.9 years; range, 12-18 years) underwent flat-panel volume CT of distal radius to determine apparent trabecu�lar bone volume fraction (BV/TV), apparent trabecular number (TbN), apparent trabecular thickness (TbTh), and apparent trabecular separation (TbSp). All subjects under�went DXA of spine, hip, and whole body to determine BMD and body composition. The means and standard deviations (SDs) of structure parameters were calculated for AN and control groups. Groups were compared (Stu�dent t test). Linear regression analysis was performed.
Results: AN subjects compared with control subjects, respectively, showed significantly lower mean values for BV/TV (0.37% � 0.05 [SD] vs 0.46% � 0.03, P = .0002) and TbTh (0.31 mm � 0.03 vs 0.39 mm � 0.03, P
Conclusions: Flat-panel volume CT is effective in evaluation of trabecu�lar structure in adolescent girls with AN and demonstrates that bone structure is abnormal in these patients com�pared with that in normal-weight control subjects despite normal BMD.