CT Assessment of Pancreatic Cancer: What Are the Gaps in Predicting Surgical Outcomes?
Pancreatic cancer outcomes remain poor, often despite aggressive surgical management. While surgery is the only option for cure and long-term survival, only about 10% of patients who undergo resection achieve 5-year overall survival in the absence of adjuvant therapy (1,2). The reason for the poor oncologic outcome is likely multifactorial and includes lymph node involvement, micro- or occult metastatic disease, positive surgical margins, or potentially lymphatic or hematogenous spread of tumor after surgical manipulation. Ultimately, these poor oncologic outcomes also indicate a significant gap in the performance of preoperative staging and determination of surgical suitability of these patients. Within this gap, the question of surgical resectability is addressed by Hong et al in this issue of Radiology (3).
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