Ionizing Radiation Use and Cancer Predisposition Syndromes in Children.
J Am Coll Radiol. 2018 Sep;15(9):1238-1239. doi: 10.1016/j.jacr.2018.04.011. Epub 2018 May 21.
Reid JR1, States LJ2.
The discovery of genetic drivers of cancer and access to genomic data have transformed the landscape of oncologic diagnosis and therapy and led to personalized treatment plans with tumor-specific immunotherapy. Treatment might be seen as the end point for personalized medicine, however, the radiologist is charged with practicing patient-centered radiology for every patient at every point in his or her disease course, including screening, diagnosis, response to therapy, and surveillance . Every radiologist providing consultation and imaging recommendations should have sound knowledge of radiation sensitivity and be prepared to weigh the risks and the benefits in formulating an imaging plan. Cancer predisposition syndromes (CPS), although rare, serve as a unique model for the avoidance of radiation exposure. An awareness of some of the more common syndromes will allow the radiologist to provide a personalized approach by recommending alternative imaging studies such as ultrasound and MRI.