Genetics of pancreatic cancer and implications for therapy.
Abdom Radiol (NY). 2018 Feb;43(2):404-414. doi: 10.1007/s00261-017-1394-y. Bhosale P1, Cox V2, Faria S2, Javadi S2, Viswanathan C2, Koay E3, Tamm E2.
Pancreatic cancer is a highly lethal disease with a dismal 5-year prognosis. Knowledge of its genetics may help in identifying new methods for patient screening, and cancer treatment. In this review, we will describe the most common mutations responsible for the genesis of pancreatic cancer and their impact on screening, patterns of disease progression, and therapy.