Computed Tomography in Cystic Fibrosis: Combining Low-Dose Techniques and Iterative Reconstruction.
J Comput Assist Tomogr. 2017 Jul/Aug;41(4):668-674. doi: 10.1097/RCT.0000000000000573. Kahn J1, Kaul D, Grupp U, Böning G, Renz D, Staab D, Schreiter V, Streitparth F.
OBJECTIVE: The aim of the study was to evaluate the impact of iterative reconstruction (IR) and low-kilovolt technique on dose reduction and image quality of chest computed tomography scans obtained in patients with cystic fibrosis (CF).
METHODS: A total of 124 CF patients were examined; group A (n = 63) was examined with a dose reduction protocol using IR and group B (n = 61) with a standard protocol using filtered back projection. Further subgroups with tube voltage modulations were established. Quantitative and qualitative image quality was assessed.
RESULTS: The radiation dose in groups with comparable image quality was approximately 40% lower using IR compared with filtered back projection. The IR protocol combined with 80-kV tube voltage showed adequate image quality with a mean effective dose of only 0.47 mSv.
CONCLUSIONS: Iterative reconstruction helps extensively reduce radiation dose by improving image quality. It permits the use of low-kilovolt protocols without significantly degrading image reading ability in the monitoring of the predominantly young patients with CF.