The second most common site of extragonadal germ cell tumors (30-40%), after the mediastinum, is the retroperitoneum. Retroperitoneal germ cell tumors (RGCTs) represent 10% of all malignant primary retroperitoneal tumors.Often patients with retroperitoneal germ cell tumors present late, after their tumors have reached large dimensions.Presenting symptoms are abdominal mass with or without pain, backache, and weight loss. Loss of ejaculation was reported in one case.
Germ Cell Tumors: Facts
Extragonadal germinal cell syndromes are rare tumors that predominantly affect young males. Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors.1,2 They are characterized by their location on the midline from the pineal gland to the coccyx
Seminoma: Facts - Most common tumor in an undescended testis - Average age of 40.5 years - Presents usually with testicular mass (75% of cases) but may present with retroperitoneal nodes or extranodal metastasis - Serum alpha fetoprotein normal in pure seminomas
